Altered salt taste response and increased tongue epithelium Scnna1 expression in adult Engrailed-2 null mice.

ABSTRACT: Sensory impairments are critical for diagnosing and characterizing neurodevelopmental disorders. Taste is a sensory modality often not well characterized. Engrailed-2 (En2) is a transcription factor critical for neural development, and mice lacking En2 (En2^-/-) display signs of impaired social interaction, cognitive processes (e.g., learning and memory, conditioned fear), and neurodevelopmental alterations. As such, En2^-/- mice display the behavioral deficits and neural impairments characteristic of the core symptoms associated with autism spectrum disorder (ASD). The objective of this study was to characterize the taste function in En2^-/- compared with En2^+/+ in adult male mice. Measuring taste responsiveness by an automated gustometer, En2 null

SUBMITTER: Gupta A 

PROVIDER: S-EPMC6487664 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature