Ontology highlight
ABSTRACT:
SUBMITTER: Song Y
PROVIDER: S-EPMC6487666 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Neuron 20190225 2
Neurons exhibit a limited ability of repair. Given that mechanical forces affect neuronal outgrowth, it is important to investigate whether mechanosensitive ion channels may regulate axon regeneration. Here, we show that DmPiezo, a Ca<sup>2+</sup>-permeable non-selective cation channel, functions as an intrinsic inhibitor for axon regeneration in Drosophila. DmPiezo activation during axon regeneration induces local Ca<sup>2+</sup> transients at the growth cone, leading to activation of nitric ox ...[more]