New insights into radioresistance in breast cancer identify a dual function of miR-122 as a tumor suppressor and oncomiR.

ABSTRACT: Radioresistance of tumor cells gives rise to local recurrence and disease progression in many patients. MicroRNAs (miRNAs) are master regulators of gene expression that control oncogenic pathways to modulate the radiotherapy response of cells. In the present study, differential expression profiling assays identified 16 deregulated miRNAs in acquired radioresistant breast cancer cells, of which miR-122 was observed to be up-regulated. Functional analysis revealed that miR-122 has a role as a tumor suppressor in parental cells by decreasing survival and promoting radiosensitivity. However, in radioresistant cells, miR-122 functions as an oncomiR by promoting survival. The transcriptomic landscape resulting from knockdown of miR-122 in radioresistant cells showed modulation of the ZNF611, ZNF

SUBMITTER: Perez-Anorve IX 

PROVIDER: S-EPMC6487688 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature