Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease.

ABSTRACT: Pulmonary inflammation in chronic obstructive pulmonary disease (COPD) is characterized by both innate and adaptive immune responses; however, their specific roles in the pathogenesis of COPD are unclear. Therefore, we investigated the roles of T and B lymphocytes and group 2 innate lymphoid cells (ILC2s) in airway inflammation and remodelling, and lung function in an experimental model of COPD using mice that specifically lack these cells (Rag1^-/- and Rora^fl/fl Il7r^Cre [ILC2-deficient] mice). Wild-type (WT) C57BL/6 mice, Rag1^-/- , and Rora^fl/fl Il7r^Cre mice were exposed to cigarette smoke (CS; 12 cigarettes twice a day, 5 days a week) for up to 12 weeks, and airway inflammation, airway remodelling (collagen deposition and a

SUBMITTER: Donovan C 

PROVIDER: S-EPMC6487813 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature