Ontology highlight
ABSTRACT:
SUBMITTER: Goncalves MD
PROVIDER: S-EPMC6487857 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20190301 6433
Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and m ...[more]