Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis.

ABSTRACT:

Introduction

Nonalcoholic steatohepatitis (NASH) afflicts 20-36% of individuals with nonalcoholic fatty liver disease (NAFLD). A lipotoxic hepatic environment, altered innate immune signaling and inflammation are defining features of progression to NASH. Activated resident liver macrophages express folate receptor beta (FR-β) which may be an indicator of progression from steatosis to NASH. The goals of this study were to characterize FR-β protein expression in human NAFLD and rodent models of NASH, and demonstrate liver targeting of an FR-β imaging agent to the liver of a rodent NASH model using FR-β.

Methods

Rat liver lysates from methionine choline deficient (MCD) fed rats, high fat diet (HFD) and methionine choline sufficient (MC+) rat controls were analyzed for hepatic F

SUBMITTER: Lake AD 

PROVIDER: S-EPMC6487882 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature