Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.

ABSTRACT:

Key points

Exposure to chronic hypoxia during gestation influences long-term health and development, including reproductive capacity, across generations. If the peri-conceptual environment in the developing oviduct is affected by gestational hypoxia, then this could have implications for later fertility and the health of future generations. In the present study, we show that the oviducts of female rats exposed to chronic hypoxia in utero have reduced telomere length, decreased mitochondrial DNA biogenesis and increased oxidative stress The results of the present study show that exposure to chronic gestational hypoxia leads to accelerated ageing of the oviduct in early adulthood and they help us understand how exposure to hypoxia during development could influence reproductive healt

SUBMITTER: Aiken CE 

PROVIDER: S-EPMC6487938 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature