Mixed-meal tolerance test to assess residual beta-cell secretion: Beyond the area-under-curve of plasma C-peptide concentration.

ABSTRACT:

Aims

Residual beta-cell secretion in type 1 diabetes is commonly assessed by area-under-curve of plasma C-peptide concentration (AUC_Cpep ) following mixed-meal tolerance test (MMTT). We aimed to investigate alternative measures of beta-cell responsiveness.

Methods

We analyzed data from 32 youth (age 7 to 17 years) undergoing MMTT within 6 months of type 1 diabetes diagnosis. We related AUC_Cpep with (a) validated mechanistic index of postprandial beta-cell responsiveness M_I accounting for glucose level during MMTT, and (b) pragmatic marker calculated as baseline plasma C-peptide concentration corrected for baseline plasma glucose concentration.

Results

Postprandial responsiveness M_I was correlated with age and BMI SDS (R

SUBMITTER: Ruan Y 

PROVIDER: S-EPMC6487945 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature