Pro-inflammatory activation of microglia in the brain of patients with sepsis.

ABSTRACT:

Aims

Experimental data suggest that systemic immune activation may create a pro-inflammatory environment with microglia activation in the central nervous system in the absence of overt inflammation, which in turn may be deleterious in conditions of neurodegenerative disease. The extent to which this is relevant for the human brain is unknown. The central aim of this study is to provide an in-depth characterization of the microglia and macrophage response to systemic inflammation.

Methods

We used recently described markers to characterize the origin and functional states of microglia/macrophages in white and grey matter in patients who died under septic conditions and compared it to those patients without systemic inflammation.

Results

We found pro-inflammatory microgl

SUBMITTER: Zrzavy T 

PROVIDER: S-EPMC6487964 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature