A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance.

ABSTRACT: Hosts can alter their strategy towards pathogens during their lifetime; that is, they can show phenotypic plasticity in immunity or life history. Immune priming is one such example, where a previous encounter with a pathogen confers enhanced protection upon secondary challenge, resulting in reduced pathogen load (i.e., resistance) and improved host survival. However, an initial encounter might also enhance tolerance, particularly to less virulent opportunistic pathogens that establish persistent infections. In this scenario, individuals are better able to reduce the negative fecundity consequences that result from a high pathogen burden. Finally, previous exposure may also lead to life-history adjustments, such as terminal investment into reproduction. Using different Drosophila melanogast

SUBMITTER: Kutzer MAM 

PROVIDER: S-EPMC6487967 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature