Dopamine genetic risk is related to food addiction and body mass through reduced reward-related ventral striatum activity.

ABSTRACT: The prevalence rate of obesity continues to rise in the U.S., but effective treatment options remain elusive resulting in increased emphasis on prevention. One such area of prevention research capitalizes on the relatively novel behavioral construct of food addiction, which has been implicated in obesity. Food addiction reflects an individual's propensity for compulsive eating despite negative consequences, and shares not only symptoms with both eating and substance use disorders but also genetic and neural correlates within neural reward-circuitry modulated by dopamine. Here, we examined associations between food addiction scores, body mass index (BMI), reward-related ventral striatum activity, and a polygenic score approximating dopamine signaling in 115 non-Hispanic Caucasian young adul

SUBMITTER: Romer AL 

PROVIDER: S-EPMC6488021 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature