Comprehensive analysis of miRNA and protein profiles within exosomes derived from canine lymphoid tumour cell lines.

ABSTRACT: Exosomes are small extracellular vesicles released from almost all cell types, which play roles in cell-cell communication. Recent studies have suggested that microenvironmental crosstalk mediated by exosomes is an important factor in the escape of tumour cells from the anti-tumour immune system in human haematopoietic malignancies. Here, we conducted comprehensive analysis of the miRNA and protein profiles within the exosomes released from four canine lymphoid tumour cell lines as a model of human lymphoid tumours. The results showed that the major miRNAs and proteins extracted from the exosomes were similar among the four cell lines. However, the miRNA profiles differed among the exosomes of each cell line, which corresponded to the expression patterns of the parent cells. In the compari

SUBMITTER: Asada H 

PROVIDER: S-EPMC6488050 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature