Functional polymorphisms in circadian positive feedback loop genes predict postsurgical prognosis of gastric cancer.

ABSTRACT:

Background

Circadian positive feedback loop (CPFL) genes (CLOCK, BAML1, and NPAS2) have been implicated in cancer initiation and progression. The purpose of this study was to explore the effects of single-nucleotide polymorphisms (SNPs) in CPFL genes on prognosis of gastric cancer (GC) patients.

Methods

Nine functional SNPs from the three CPFL genes were genotyped in a cohort of 704 GC patients undergoing resection. Multivariate Cox regression model and Kaplan-Meier curve were used for prognosis analysis.

Results

Among the nine SNPs, rs11133399 in CLOCK, rs1044432 and rs2279284 in BAML1 were significantly associated with GC overall survival and recurrence-free survival. The unfavorable genotypes of these SNPs showed a cumulative effect on GC prognosis. Multivariate as

SUBMITTER: Chen Y 

PROVIDER: S-EPMC6488121 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature