A systematic review of the HPV-attributable fraction of oropharyngeal squamous cell carcinomas in Germany.

ABSTRACT: The prevalence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing globally while the prevalence of other head and neck cancers is decreasing. The most likely reasons for this are a decreasing influence of smoking and the growing relevance of infections with the human papilloma virus (HPV) as a risk factor. A rise in the HPV-attributable fraction (HPV-AF) of OPSCC has been observed in many countries, yet a comprehensive review of prevalence rates and trends in Germany is lacking. To determine the current HPV-AF of OPSCC in Germany and to assess whether it has changed during the last decades, we performed a systematic literature review. We screened Medline and EMBASE for studies that reported the tumor HPV status of newly diagnosed OPSCC patients treated at medical centers in Ger

SUBMITTER: Reuschenbach M 

PROVIDER: S-EPMC6488137 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature