Liver resection versus transarterial chemoembolization for the treatment of intermediate-stage hepatocellular carcinoma.

ABSTRACT:

Background

The role of transarterial chemoembolization (TACE) as the standard treatment for intermediate-stage hepatocellular carcinoma (HCC) is being challenged by increasing studies supporting liver resection (LR); but evidence of survival benefits of LR is lacking. We aimed to compare the overall survival (OS) of LR with that of TACE for the treatment of intermediate-stage HCC in cirrhotic patients.

Methods

A Markov model, comparing LR with TACE over 15 years, was developed based on the data from 31 literatures. Additionally, external validation of the model was performed using a data set (n = 1735; LR: 701; TACE: 1034) from a tertiary center with propensity score matching method. We conducted one-way and two-way sensitivity analyses, in addition to a Monte Carlo analysis

SUBMITTER: Chen S 

PROVIDER: S-EPMC6488138 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature