High expression of long non-coding RNA MALAT1 in breast cancer is associated with poor relapse-free survival.

ABSTRACT:

Purpose

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been identified as a prognostic marker for the metastasis of early-stage non-small cell lung cancer (NSCLCs). We studied MALAT1 expression in breast cancer in relation to disease features and patient survival.

Methods

Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was used to measure MALAT1 expression in tumor samples of 509 breast cancer patients. Hazards ratios (HRs) and 95% confidence intervals (CIs) were calculated to assess the association between MALAT1 expression and breast cancer survival using the Cox proportional hazards regression model, and the analysis was adjusted for age at surgery, tumor grade, disease stage, and hormone receptor status. Meta-analysis of multip

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6488226 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature