The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves.

ABSTRACT:

Background

An individual with a bicuspid aortic valve (BAV) runs a substantially higher risk of developing aneurysm in the ascending aorta compared to the normal population with tricuspid aortic valves (TAV). Aneurysm formation in patients with BAV and TAV is known to be distinct at the molecular level but the underlying mechanisms are undefined. Here, we investigated the still incompletely described role of microRNAs (miRNAs), important post-transcriptional regulators of gene expression, in such aortic disease of patients with BAV as compared with TAV.

Methods and results

Using a system biology approach, based on data obtained from proteomic analysis of non-dilated aortas from BAV and TAV patients, we constructed a gene-interaction network of regulatory microRNAs associated

SUBMITTER: Maleki S 

PROVIDER: S-EPMC6488227 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature