Pharmacotherapy of relapsed/refractory chronic lymphocytic leukemia.

ABSTRACT:

Introduction

The treatment of relapsed/refractory (RR) CLL has been revolutionized by the advent of the new oral inhibitors of B-cell receptor (BCR) signaling and the pro-survival protein, B-cell lymphoma 2 (BCL2). Additionally, new and more potent monoclonal antibodies against CD20 have replaced/may replace rituximab in many settings. Areas covered: Herein, we review the entire therapeutic landscape of RR CLL, with particular attention to the new small-molecule kinase inhibitors and BH3-mimetics. We discuss preclinical data with these agents in CLL, cover available efficacy and safety information, and examine potential resistance mechanisms and possible rational combinations to circumvent them. Expert opinion: The availability of potent and selective inhibitors of BCR signaling an

SUBMITTER: Abou Zahr A 

PROVIDER: S-EPMC6488229 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature