Resting-state amplitude of low-frequency fluctuation is associated with suicidal ideation.

ABSTRACT: BACKGROUND:Identifying brain activity patterns that are associated with suicidal ideation (SI) may help to elucidate its pathogenesis and etiology. Suicide poses a significant public health problem, and SI is a risk factor for suicidal behavior. METHODS:Forty-one unmedicated adult participants in a major depressive episode (MDE), 26 with SI on the Beck Scale for Suicidal Ideation and 15 without SI, underwent resting-state functional magnetic resonance imaging scanning. Twenty-one healthy volunteers (HVs) were scanned for secondary analyses. Whole brain analysis of both amplitude of low-frequency fluctuations (ALFFs) and fractional ALFF was performed in MDE subjects to identify regions where activity was associated with SI. RESULTS:Subjects with SI had greater ALFF than those without SI in

SUBMITTER: Lan MJ 

PROVIDER: S-EPMC6488362 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature