Reproducibility of interictal spike propagation in children with refractory epilepsy.

ABSTRACT:

Objective

Interictal spikes are a characteristic feature of invasive electroencephalography (EEG) recordings in children with refractory epilepsy. Spikes frequently co-occur across multiple brain regions with discernable latencies, suggesting that spikes can propagate through distributed neural networks. The purpose of this study was to examine the long-term reproducibility of spike propagation patterns over hours to days of interictal recording.

Methods

Twelve children (mean age 13.1 years) were retrospectively studied. A mean ± standard deviation (SD) of 47.2 ± 40.1 hours of interictal EEG recordings were examined per patient (range 17.5-166.5 hours). Interictal recordings were divided into 30-minute segments. Networks were extracted based on the frequency of spike coactiv

SUBMITTER: Tomlinson SB 

PROVIDER: S-EPMC6488404 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature