Vessel-specific quantification of absolute myocardial blood flow, myocardial flow reserve and relative flow reserve by means of fused dynamic ¹³NH₃ PET and CCTA: Ranges in a low-risk population and abnormality criteria.

ABSTRACT:

Objectives

The goal of the present work is to present a novel methodology for the extraction of MBF, MFR and RFR along coronary arteries by means of multimodality image fusion of dynamic PET and CCTA images.

Background

FFR is the reference standard to identify flow-limiting lesions, but its invasiveness limits broad application. New noninvasive methodologies are warranted to stratify patients and guide treatment.

Methods

A group of 16 low-risk CAD subjects who underwent both ¹³NH₃ PET and CCTA were analyzed. Image fusion techniques were employed to align the studies and CCTA-derived anatomy used to identify coronaries trajectories. MBF was calculated by means of a 1-tissue compartmental model for the standard vascular territories and along patien

SUBMITTER: Piccinelli M 

PROVIDER: S-EPMC6488439 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature