Effectiveness of Dettol Antiseptic Liquid for Inactivation of Ebola Virus in Suspension.

ABSTRACT: The efficacy of Dettol Antiseptic Liquid (DAL) for inactivating Ebola virus (Makona C07 variant) (EBOV/Mak) within an organic load in suspension was evaluated per ASTM E1052-11. Three DAL lots were evaluated at dilutions of 1:10, 1:20, and 1:40, with contact times of 0.5, 1, 5, and 10 min. Approximately 7 log₁₀ tissue culture infectious dose₅₀ (TCID₅₀) of EBOV/Mak was exposed to DAL at ambient temperature. Each dilution tested reduced the infectious EBOV/Mak titer by ~5 log₁₀ within one min. Detectable virus was still present after an 0.5-min exposure, but each DAL dilution caused >4 log₁₀ reduction within this time. Detection of virus below the limit of detection of the TCID₅₀ assay was assessed by inoculating flasks of Ver

SUBMITTER: Cutts TA 

PROVIDER: S-EPMC6488606 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature