Genetic risk score has added value over initial clinical grading stage in predicting disease progression in age-related macular degeneration.

ABSTRACT: Several prediction models for progression of age-related macular degeneration (AMD) have been developed, but the added value of using genetic information in those models in addition to clinical characteristics is ambiguous. In this prospective cohort study, we explored the added value of genetics using a genetic risk score (GRS) based on 52 AMD-associated variants, in addition to the clinical severity grading at baseline as quantified by validated drusen detection software, to predict disease progression in 177 AMD patients after 6.5 years follow-up. The GRS was strongly associated with the drusen coverage at baseline (P < 0.001) and both the GRS and drusen coverage were associated with disease progression. When the GRS was added as predictor in addition to the drusen coverage, R²

SUBMITTER: Heesterbeek TJ 

PROVIDER: S-EPMC6488669 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature