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Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient.

ABSTRACT: The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.

SUBMITTER: Ramdhan ND 

PROVIDER: S-EPMC6488682 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Genomic analysis of a novel nontoxigenic <i>Corynebacterium diphtheriae</i> strain isolated from a cancer patient.

Ramdhan N D ND   Blom J J   Sutcliffe I C IC   Pereira-Ribeiro P M A PMA   Santos C S CS   Mattos-Guaraldi A L AL   Burkovski A A   Sangal V V  

New microbes and new infections 20190409

The genome of a novel nontoxigenic <i>Corynebacterium diphtheriae,</i> strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses <i>spaD</i>-type and <i>spaH</i>-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to under  ...[more]

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