Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi T
PROVIDER: S-EPMC6488753 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
JACC. Basic to translational science 20190429 2
High-mobility group box 1 (HMGB1) is a deoxyribonucleic acid (DNA)-binding protein associated with DNA repair. Decreased nuclear HMGB1 expression and increased DNA damage response (DDR) were observed in human failing hearts. DNA damage and DDR as well as cardiac remodeling were suppressed in cardiac-specific HMGB1 overexpression transgenic mice after angiotensin II stimulation as compared with wild-type mice. In vitro, inhibition of HMGB1 increased phosphorylation of extracellular signal-related ...[more]