Hormetic Dose Response of NaAsO₂ on Cell Proliferation of Prostate Cells in Vitro: Implications for Prostate Cancer Initiation and Therapy.

ABSTRACT: Sodium meta-arsenite (NaAsO₂) has been suggested to play a role both in initiation/progression of prostate cancer and as a future antiprostate cancer drug. We have studied the effects of NaAsO₂ on cell proliferation of prostate cancer and noncancer cells, breast cancer cells, and adrenocortical carcinoma cells in vitro. Further, we have investigated the effect of NaAsO₂ on the androgen receptor. We report that NaAsO₂ alters the cell proliferation of prostate cells, in a hormetic manner, by increasing cell proliferation at low concentrations and decreasing the cell proliferation at high concentrations. No activation of the androgen receptor was detected. We conclude that NaAsO₂ is able to increase cell proliferation of prostate cells in

SUBMITTER: Lundqvist J 

PROVIDER: S-EPMC6488789 | biostudies-literature | 2019 Apr-Jun

REPOSITORIES: biostudies-literature