Risk Factors for Retinopathy in Type 1 Diabetes: The DCCT/EDIC Study.

ABSTRACT:

Objective

The Diabetes Control and Complications Trial (DCCT) demonstrated that intensive therapy reduced the development and progression of retinopathy in type 1 diabetes (T1D) compared with conventional therapy. The Epidemiology of Diabetes Interventions and Complications (EDIC) study observational follow-up showed persistent benefits. In addition to glycemia, we now examine other potential retinopathy risk factors (modifiable and nonmodifiable) over more than 30 years of follow-up in DCCT/EDIC.

Research design and methods

The retinopathy outcomes were proliferative diabetic retinopathy (PDR), clinically significant macular edema (CSME), and ocular surgery. The survival (event-free) probability was estimated using the Kaplan-Meier method. Cox proportional hazards models as

SUBMITTER: Hainsworth DP 

PROVIDER: S-EPMC6489114 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature