Rapid and Accurate Determination of Nanopore Ionic Current Using a Steric Exclusion Model.

ABSTRACT: Nanopore sensing has emerged as a versatile approach to detection and identification of biomolecules. Presently, researchers rely on experience and intuition for choosing or modifying the nanopores to detect a target analyte. The field would greatly benefit from a computational method that could relate the atomic-scale geometry of the nanopores and analytes to the blockade nanopore currents they produce. Existing computational methods are either computationally too expensive to be used routinely in experimental laboratories or not sensitive enough to account for the atomic structure of the pore and the analytes. Here, we demonstrate a robust and inexpensive computational approach-the steric exclusion model (SEM) of nanopore conductance-that is orders of magnitude more efficient than all-at

SUBMITTER: Wilson J 

PROVIDER: S-EPMC6489136 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature