High levels of circulating interferons type I, type II and type III associate with distinct clinical features of active systemic lupus erythematosus.

ABSTRACT:

Background and aim

Interferons (IFNs) are considered to be key molecules in the pathogenesis of systemic lupus erythematosus (SLE). We measured levels of type I, II and III IFNs in a large cohort of patients with systemic lupus erythematosus (SLE) and controls and explored associations among high levels of different IFN types and distinct SLE features.

Methods

Four hundred ninety-seven well-characterized SLE patients and 322 population controls were included. Disease activity was assessed by SLE Disease Activity Index (SLEDAI) and Systemic Lupus Activity Measure (SLAM). Functional type I IFN activity was estimated by a WISH reporter cell assay. Levels of IFN-γ were estimated by MSD 30-plex assay. IFN-α and IFN-λ1 were measured by ELISA. Values above the third quartile of pat

SUBMITTER: Oke V 

PROVIDER: S-EPMC6489203 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature