Hsa_circ_0005379 regulates malignant behavior of oral squamous cell carcinoma through the EGFR pathway.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) is an oral and maxillofacial malignancy with a high incidence worldwide. Accumulating evidence indicates that circular RNAs (circRNAs) play a vital role in modulating tumor development. However, the mechanism of circRNA action in human OSCC remains largely unknown.

Methods

By using high-throughput transcriptome sequencing technology, we conducted a comprehensive study of circRNAs in human OSCC. The effect of circRNA hsa_circ_0005379 on OSCC tissues and cell lines was monitored by qRT-PCR, Transwell assay, flow cytometry, and western blot analysis. Xenograft mouse models were used to assess tumor growth and animal survival.

Results

We found that circRNA hsa_circ_0005379 expression is significantly lower in OSCC tissue comp

SUBMITTER: Su W 

PROVIDER: S-EPMC6489207 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature