The presence of bacteria varies between colorectal adenocarcinomas, precursor lesions and non-malignant tissue.

ABSTRACT:

Background

A causal association has been suggested between certain bacteria and colorectal cancer (CRC). Only a few studies have, however, investigated the presence of these bacteria directly in colon tissue with conflicting results. It is thus uncertain which role they may have in prognosis and carcinogenesis of CRC.

Methods

Formalin-fixed and paraffin-embedded (FFPE) colorectal tissue samples from patients diagnosed with colorectal cancer (CRC)(tumor and paired normal tissue, n = 99), adenomas (n = 96), or diverticular disease (n = 104) were tested for the presence and bacterial load of Streptococcus gallolyticus (S. gallolyticus), Fusobacterium nucleatum (F. nucleatum), and Bacteroides fragilis (B. fragilis) using quantitative PCR. A subsequent broader search was conducte

SUBMITTER: Bundgaard-Nielsen C 

PROVIDER: S-EPMC6489238 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature