PwrEWAS: a user-friendly tool for comprehensive power estimation for epigenome wide association studies (EWAS).

ABSTRACT:

Background

When designing an epigenome-wide association study (EWAS) to investigate the relationship between DNA methylation (DNAm) and some exposure(s) or phenotype(s), it is critically important to assess the sample size needed to detect a hypothesized difference with adequate statistical power. However, the complex and nuanced nature of DNAm data makes direct assessment of statistical power challenging. To circumvent these challenges and to address the outstanding need for a user-friendly interface for EWAS power evaluation, we have developed pwrEWAS.

Results

The current implementation of pwrEWAS accommodates power estimation for two-group comparisons of DNAm (e.g. case vs control, exposed vs non-exposed, etc.), where methylation assessment is carried out using the Illumi

SUBMITTER: Graw S 

PROVIDER: S-EPMC6489300 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature