Plasmids of Shigella flexneri serotype 1c strain Y394 provide advantages to bacteria in the host.

ABSTRACT:

Background

Shigella flexneri has an extremely complex genome with a significant number of virulence traits acquired by mobile genetic elements including bacteriophages and plasmids. S. flexneri serotype 1c is an emerging etiological agent of bacillary dysentery in developing countries. In this study, the complete nucleotide sequence of two plasmids of S. flexneri serotype 1c strain Y394 was determined and analysed.

Results

The plasmid pINV-Y394 is an invasive or virulence plasmid of size 221,293 bp composed of a large number of insertion sequences (IS), virulence genes, regulatory and maintenance genes. Three hundred and twenty-eight open reading frames (ORFs) were identified in pINV-Y394, of which about a half (159 ORFs) were identified as IS elements. Ninety-seven ORFs wer

SUBMITTER: Parajuli P 

PROVIDER: S-EPMC6489325 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature