Sustained interleukin-10 delivery reduces inflammation and improves motor function after spinal cord injury.

ABSTRACT:

Background

The anti-inflammatory cytokine interleukin-10 (IL-10) has been explored previously as a treatment method for spinal cord injury (SCI) due to its ability to attenuate pro-inflammatory cytokines and reduce apoptosis. Primary limitations when using systemic injections of IL-10 are that it is rapidly cleared from the injury site and that it does not cross the blood-spinal cord barrier.

Objective

Here, mineral-coated microparticles (MCMs) were used to obtain a local sustained delivery of IL-10 directly into the injury site after SCI.

Methods

Female Sprague-Dawley rats were contused at T10 and treated with either an intraperitoneal injection of IL-10, an intramedullary injection of IL-10, or MCMs bound with IL-10 (MCMs+IL-10). After treatment, cytokine levels wer

SUBMITTER: Hellenbrand DJ 

PROVIDER: S-EPMC6489327 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature