Antibiotic prophylaxis in clean-contaminated head and neck cases with microvascular free flap reconstruction: A systematic review and meta-analysis.

ABSTRACT:

Background

Optimal antibiotic prophylaxis duration in head and neck clean-contaminated free-flap cases is unknown.

Methods

A systematic review/meta-analysis was conducted using PubMed/MEDLINE, Cochrane Library, Web-of-Science, and Scopus databases.

Results

Of the 3755 searched articles, 5 articles were included for a total of 861 patients. The recipient surgical site infection risk was significantly higher in patients receiving prophylactic antibiotics for ≤24 hours compared to >24 hours (relative risk [RR] 1.56; 95% confidence interval [CI] 1.13-2.14). In the post hoc multivariate analysis based on available individual-level data on 697 patients from 3 studies, the risk of surgical site infection for ≤24 hours versus >24 hours was not significant after adjusting for

SUBMITTER: Haidar YM 

PROVIDER: S-EPMC6489503 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature