Stanniocalcin 1 in tumor microenvironment promotes metastasis of ovarian cancer.

ABSTRACT: Background: Tumor metastasis is the major challenge for ovarian cancer treatment. Cancer-associated fibroblasts (CAFs), a major component existing in tumor microenvironment, can secrete several cytokines to interact with cancer epithelial cells, and promote cancer metastasis. Stanniocalcin 1 (STC1), a secretory glycoprotein hormone, has been proven to be an important factor in ovarian tumorigenesis. Methods: In this study, we focused on the functional role of STC1 in ovarian cancer microenvironment, investigated STC1's effects on the proliferation and metastasis of ovarian cancer cells, and explored the molecular mechanism underlying STC1-mediated cancer metastasis. Results: By analyzing the GEO dataset and examined STC1 expression in CAFs isolated from ovarian cancer patients, we found th

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6489642 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature