Prevalence and pharmacologic management of familial hypercholesterolemia in an unselected contemporary cohort of patients with stable coronary artery disease.

ABSTRACT:

Introduction

Familial hypercholesterolemia (FH) is an inherited disorder characterized by elevated plasma levels of low-density lipoprotein cholesterol (LDL-C) associated with premature cardiovascular disease.

Methods

Using the data from the START (STable Coronary Artery Diseases RegisTry) study, a nationwide, prospective survey on patients with stable coronary artery disease (CAD), we described prevalence and lipid lowering strategies commonly employed in these patients. The study population was divided into "definite/probable FH," defined as a Dutch Lipid Clinic Network (DLCN) score ≥6, "possible FH" with DLCN 3-5, and "unlikely FH" in presence of a DLCN <3.

Results

Among the 4030 patients with the DLCN score available, 132 (3.3%) were classified as FH (2.3% with de

SUBMITTER: De Luca L 

PROVIDER: S-EPMC6489755 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature