Low-density lipoprotein-cholesterol lowering in individuals at intermediate cardiovascular risk: Percent reduction or target level?

ABSTRACT:

Background

Recommendations for blood cholesterol management differ across different guidelines.

Hypothesis

Lipid-lowering strategies based on low-density lipoprotein-cholesterol (LDL-c) percent reduction or target concentration may have different effects on the expected cardiovascular benefit in intermediate-risk individuals.

Methods

We selected individuals between 40 and 75 years of age with 10-year risk for atherosclerotic cardiovascular disease (ASCVD) between 5.0% and <7.5% who underwent a routine health screening. For every subject, we simulated a strategy based on a 40% LDL-c reduction (S_40% ) and another strategy based on achieving LDL-c target ≤100 mg/dL (S_target-100 ). The cardiovascular benefit was estimated assuming a 22% relative risk

SUBMITTER: Cesena FHY 

PROVIDER: S-EPMC6489793 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature