Long noncoding RNA LINC00152 is a potential prognostic biomarker in patients with high-grade glioma.

ABSTRACT:

Aims

To investigate the role of LINC00152 in high-grade glioma (HGG).

Methods

We collected data from the Chinese Glioma Genome Atlas (CGGA) microarray, CGGA RNA sequencing, and GSE16011 datasets to evaluate the expression and prognostic relationship of LINC00152 in patients with HGGs. A knockdown assay was performed to determine the function of LINC00152 in glioma development and progression in vitro and in vivo.

Results

The expression of LINC00152 was increased with glioma grade, especially in the mesenchymal TCGA subtype. LINC00152 was independently associated with poor prognosis, and the overall survival (OS) of the high expression group was shorter than the low expression group (median OS 14.77 vs 9.65 months; P = 0.0216) in the CGGA microarray dataset. The result

SUBMITTER: Wang W 

PROVIDER: S-EPMC6489806 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature