Identification of novel immune-relevant drug target genes for Alzheimer's Disease by combining ontology inference with network analysis.

ABSTRACT:

Aims

Alzheimer's disease (AD) is one of the leading causes of death in elderly people. Its pathogenesis is greatly associated with the abnormality of immune system. However, only a few immune-relevant AD drug target genes have been discovered up to now, and it is speculated that there are still many potential drug target genes of AD (at least immune-relevant genes) to be discovered. Thus, this study was designed to identify novel AD drug target genes and explore their biological properties.

Methods

A combinatorial approach was adopted for the first time to discover AD drug targets by collectively considering ontology inference and network analysis. Moreover, a novel strategy limiting the distance of reasoning and in turn reducing noise interference was further proposed to im

SUBMITTER: Han ZJ 

PROVIDER: S-EPMC6489817 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature