Identification of clinically relevant phenotypes in patients with Ebstein anomaly.

ABSTRACT:

Background

Ebstein anomaly (EA) is a heterogeneous congenital heart defect (CHD), frequently accompanied by diverse cardiac and extracardiac comorbidities, resulting in a wide range of clinical outcomes.

Hypothesis

Phenotypic characterization of EA patients has the potential to identify variables that influence prognosis and subgroups with distinct contributing factors.

Methods

A comprehensive cross-sectional phenotypic characterization of 147 EA patients from one of the main referral institutions for CHD in Colombia was carried out. The most prevalent comorbidities and distinct subgroups within the patient cohort were identified through cluster analysis.

Results

The most prevalent cardiac comorbidities identified were atrial septal defect (61%), Wolff-Parkinso

SUBMITTER: Cabrera R 

PROVIDER: S-EPMC6489938 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature