Preferential modulation of the lateral habenula activity by serotonin-2A rather than -2C receptors: Electrophysiological and neuroanatomical evidence.

ABSTRACT:

Aims

Serotonergic (5-HT) modulation of the lateral habenula (LHb) activity is central in normal and pathologic conditions such as mood disorders. Among the multiple 5-HT receptors (5-HTRs) involved, the 5-HT_2C R seems to play a pivotal role. Yet, the role of 5-HT_2A Rs in the control of the LHb neuronal activity is completely unknown.

Methods

Single-cell extracellular recording of the LHb neurons was used in rats to study the effect of the general activation and blockade of the 5-HT_2C R and 5-HT_2A R with Ro 60-0175 and SB242084, TCB-2 and MDL11939, respectively. The expression of both receptors in the LHb was confirmed using immunohistochemistry.

Results

Cumulative doses (5-640 μg/kg, iv) of Ro 60-0175 and TCB-2 affected the

SUBMITTER: Delicata F 

PROVIDER: S-EPMC6490100 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature