DNA Motifs Are Not General Predictors of Recombination in Two Drosophila Sister Species.

ABSTRACT: Meiotic recombination is crucial for chromosomal segregation and facilitates the spread of beneficial and removal of deleterious mutations. Recombination rates frequently vary along chromosomes and Drosophila melanogaster exhibits a remarkable pattern. Recombination rates gradually decrease toward centromeres and telomeres, with a dramatic impact on levels of variation in natural populations. Two close sister species, Drosophila simulans and Drosophila mauritiana do not only have higher recombination rates but also exhibit a much more homogeneous recombination rate that only drops sharply very close to centromeres and telomeres. Because certain sequence motifs are associated with recombination rate variation in D. melanogaster, we tested whether the difference in recombination landscape be

SUBMITTER: Howie JM 

PROVIDER: S-EPMC6490297 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature