Heart rate and outcome in heart failure with reduced ejection fraction: Differences between atrial fibrillation and sinus rhythm-A CIBIS II analysis.

ABSTRACT:

Background

Heart rate has been associated with prognosis in patients with heart failure with reduced ejection fraction (HFREF) and sinus rhythm; whether this also holds true in patients with atrial fibrillation (AF) is unknown.

Hypothesis

To evaluate cardiac rhythm and baseline heart rate and the influence of outcome in patients with HFREF enrolled in the Cardiac Insufficiency Bisoprolol Study II.

Methods

In total, 2539 patients were stratified according to their baseline heart rhythm (AF or sinus rhythm) and into quartiles of heart rate (≤70 bpm, 71-78 bpm, 79-90 bpm, and >90 bpm). The primary outcome was all-cause mortality. Mean follow-up was 1.3 years.

Results

Mean age was 61 years, mean left ventricular ejection fraction was 28%, and 80% were male. A total

SUBMITTER: Mulder BA 

PROVIDER: S-EPMC6490317 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature