Interleukin-37 elevation in patients with atrial fibrillation.

ABSTRACT:

Background

Inflammation is closely related to atrial fibrillation (AF) pathogenesis, and interleukin-37 (IL-37) represents a new member of the anti-inflammatory cytokines.

Hypothesis

IL-37 might play an important role in AF development and act as a potential risk factor for AF diagnosis.

Methods

The mRNA level of IL-37 in peripheral blood mononuclear cells (PBMCs) and serum IL-37 levels in AF patients and healthy controls were measured by real-time polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). PBMCs from AF patients were stimulated with recombinant IL-37. Levels of pro-inflammatory cytokines IL-6 and C-reactive protein were determined by RT-PCR and ELISA.

Results

IL-37 mRNAs and serum protein levels were higher in patients wi

SUBMITTER: Li W 

PROVIDER: S-EPMC6490375 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature