Guideline-based statin/lipid-lowering therapy eligibility for primary prevention and accuracy of coronary artery calcium and clinical cardiovascular events: The Multi-Ethnic Study of Atherosclerosis (MESA).

ABSTRACT:

Background

With multiple cholesterol guidelines, we evaluated the accuracy of recommended statin therapy on identifying coronary artery calcium (CAC) and cardiovascular disease (CVD) events by 2004 NCEP/ ATP III, 2016 ESC/EAS, and 2013 ACC/AHA guidelines.

Hypothesis

ACC/AHA guidelines are more accurate in identifying persons at risk for CVD.

Methods

5002/6814 participants age <75 years and free of CVD were included. CAC categories (>0, ≥100, and ≥300) and 10 years of CVD outcomes were considered. Sensitivity (SN), specificity (SP), positive and negative predictive value (PPV and NPV), and likelihood ratios (LR) were calculated. Mean age was 59 years; 47% of subjects were males.

Results

1297 (26%), 1381 (28%), and 2538 (51%) had class I indications for statin/LL

SUBMITTER: Flueckiger P 

PROVIDER: S-EPMC6490381 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature