Urinary [TIMP-2] × [IGFBP7] for risk prediction of acute kidney injury in decompensated heart failure.

ABSTRACT:

Background

In acute decompensated heart failure (ADHF) the risk of acute kidney injury (AKI) is high. Early detection of patients at risk for AKI is important. We tested urinary [TIMP-2] × [IGFBP7], a new US Food and Drug Administration-cleared test to assess AKI risk, in a cohort of hospitalized ADHF patients.

Hypothesis

In patients with ADHF, urinary [TIMP-2] × [IGFBP7] is associated with moderate to severe AKI and related to increased mortality.

Methods

We enrolled 400 patients in the emergency department at Robert-Bosch Hospital, Stuttgart, Germany. We examined the predictive ability of urinary [TIMP-2] × [IGFBP7] (units: [ng/mL]² /1000) for development of AKI stage 2 or 3 within 24 hours of sample collection in patients with ADHF. Operating characteris

SUBMITTER: Schanz M 

PROVIDER: S-EPMC6490429 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature