Long-term cardiovascular mortality after radiotherapy for breast cancer: A systematic review and meta-analysis.

ABSTRACT:

Background

Radiotherapy (RT) is frequently associated with late cardiovascular (CV) complications. The mean cardiac dose from irradiation of a left-sided breast cancer is much higher than that for a right-sided breast cancer. However, data is limited on the long-term risks of RT on CV mortality.

Hypothesis

RT for breast cancer is associated with long term CV mortality and left sided RT carries a greater mortality than right sided RT.

Methods

We searched PubMed, Cochrane Central, Embase, EBSCO, Web of Science, and CINAHL databases from inception through December 2015. Studies reporting CV mortality with RT for left- vs right-sided breast cancers were included. The principal outcome of interest was CV mortality. We calculated summary risk ratio (RR) and 95% confidence i

SUBMITTER: Sardar P 

PROVIDER: S-EPMC6490535 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature