Prognostic impact of diastolic dysfunction in systolic heart failure-A cross-project analysis from the German Competence Network Heart Failure.

ABSTRACT:

Background

We investigated the modifying role and prognostic importance of diastolic dysfunction (DD) in patients with heart failure and systolic dysfunction (SD).

Hypothesis

The echocardiographic evaluation of diastolic function in patients with SD provides further prognostic information.

Methods

From the German Competence Network Heart Failure, 1046 heart failure patients with reduced left ventricular ejection fraction (LVEF; <50%) were echocardiographically studied and followed for a median of 5 years. SD was subdivided into nonsevere (LVEF 36%-49%) and severe (LVEF ≤35%); DD was subdivided into nonsevere (E/E' <15) and severe (E/E' ≥15).

Results

In general, severe SD was associated with higher hazard ratios (HRs; 2-fold to 3.5-fold) for all endpoints (all-c

SUBMITTER: Luers C 

PROVIDER: S-EPMC6490547 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature