Aspirin and the risk of cardiovascular events in atherosclerosis patients with and without prior ischemic events.

ABSTRACT:

Background

The benefit of aspirin among patients with stable atherosclerosis without a prior ischemic event is not well defined.

Hypothesis

Aspirin would be of benefit in outpatients with atherosclerosis with prior ischemic events, but not in those without ischemic events.

Methods

Subjects from the Reduction of Atherothrombosis for Continued Health registry were divided according to prior ischemic event (n =21 724) vs stable atherosclerosis, but no prior ischemic event (n = 11 872). Analyses were propensity score matched. Aspirin use was updated at each clinic visit and considered as a time-varying covariate. The primary outcome was the first occurrence of cardiovascular death, myocardial infarction, or stroke.

Results

In the group with a prior ischemic event,

SUBMITTER: Bavry AA 

PROVIDER: S-EPMC6490549 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature